GenePage for the yjgH gene of Escherichia coli K-12

Primary Gene Name: yjgH
EcoGene Accession Number: EG12527
K-12 Gene Accession Number: ECK4242
MG1655 Gene Identifier: b4248
Gene Name Mnemonic: Systematic nomenclature
Alternate Gene Symbols: None
Description: Putative reactive intermediate deaminase, UPF0076 family; reaction intermediate detoxification
  # bp Upstream # bp Downstream
MW: 14590.27 ---------131 aa Pre-Run BlastP UniProt
Pre-Run BlastP NR+Env
Left End: 4472814
Left Intergenic Region

Name: pyrL_yjgH

Length: 280 bp gap

Orientation: Codirectional-

Left_end: 4472534

Right_end: 4472813

Centisome: 96.36

Genomic Address
Counterclockwise
Minute or Centisome (%) = 96.36
Right End: 4473209
Right Intergenic Region

Name: yjgH_bdcA

Length: 130 bp gap

Orientation: Codirectional-

Left_end: 4473210

Right_end: 4473339

Centisome: 96.37

The Salmonella PF01042 family member RidA(YjgF) is an enamine/imine deaminase required for the detoxification of reactive intermediates of the PLP-dependent threonine dehydratase IlvA, releasing ammonia in a water-based reaction indicative of the low water environment of the cell (Lambrecht, 2012). RidA(YjgF), RutC, TdcF, YoaB and YjgH are paralogs and members of a highly conserved RidA(YjgF) family (pfam:PF01042) with diverse mutant phenotypes; the family members form homotrimers, some binding 2-ketoglutarate or related compounds, and all are probably reactive intermediate deaminases. The rat homolog PSP (perchloric acid-soluble protein) has been reported to have endoribonuclease activity, Endoribonuclease L, against ss mRNA, inhibiting translation.

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BamHI EcoRI HindIII