GenePage for the nanM gene of Escherichia coli K-12

Primary Gene Name: nanM
EcoGene Accession Number: EG12562
K-12 Gene Accession Number: ECK4301
MG1655 Gene Identifier: b4310
Gene Name Mnemonic: N-Acetylneuraminate
Alternate Gene Symbols: yjhT
Description: N-acetylneuraminic acid mutarotase
  # bp Upstream # bp Downstream
MW: 39572.23 ---------368 aa Pre-Run BlastP UniProt
Pre-Run BlastP NR+Env
Left End: 4537659
Left Intergenic Region

Name: nanS_nanM

Length: 64 bp gap

Orientation: Codirectional-

Left_end: 4537595

Right_end: 4537658

Centisome: 97.76

Genomic Address
Counterclockwise
Minute or Centisome (%) = 97.76
Right End: 4538765
Right Intergenic Region

Name: nanM_nanC

Length: 19 bp gap

Orientation: Codirectional-

Left_end: 4538766

Right_end: 4538784

Centisome: 97.78

NanM has N-acetylneuraminic acid mutarotase activity and is required for the efficient utilization of N-acetylneuraminic acid (Da Severi, 2008). The first 19 are a type I signal peptide; the processed mature N-terminal fragment was confirmed by MS as 2/24 NamM(YjhT) peptides matching the processed N-terminus (Maillet, 2007). The first 19 aa are confirmed to be a type I signal peptide by electrospray MS of the C-terminally His-tagged mature protein (obs. MW = 38686) expressed from a clone, confirming the cleavage site (Da Severi, 2008). NanM has six Kelch domain propeller blades (Da Severi, 2008; Pfam:PF01344).

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BamHI EcoRI HindIII