GenePage for the lptA gene of Escherichia coli K-12

Primary Gene Name: lptA
EcoGene Accession Number: EG12618
K-12 Gene Accession Number: ECK3189
MG1655 Gene Identifier: b3200
Gene Name Mnemonic: LPS transport
Alternate Gene Symbols: yhbN
Description: LPS export ABC transporter periplasmic binding protein; Lipid A binding protein; LPS export and assembly protein
  # bp Upstream # bp Downstream
Verified Start MW: 20126.88 ---------185 aa Pre-Run BlastP UniProt
Pre-Run BlastP NR+Env
Left End: 3343380
Left Intergenic Region

Name: lptC_lptA

Length: 32 bp overlap

Orientation: Codirectional+

Left_end: 3343380

Right_end: 3343411

Centisome: 72.03

Genomic Address
Clockwise
Minute or Centisome (%) = 72.03
Right End: 3343937
Right Intergenic Region

Name: lptA_lptB

Length: 6 bp gap

Orientation: Codirectional+

Left_end: 3343938

Right_end: 3343943

Centisome: 72.04

LptC binds LPS in vitro and LptA can displace LPS from LptC, but not the reverse, consistent with an LPS export pathway (Tran, 2010). LptA is localized to the periplasm (Sperandeo, 2007). LptA depletion results in rifampicin/bile salts sensitivity, indicative of an outer membrane integrity defect (Sperandeo, 2006). The failure to produce a viable deletion strain indicates that lptA is an essential gene (Baba, 2006). LptA is paralogous to LptD(OstA,Imp). The first 27 aa of LptA are a type I signal peptide. lptAB expression is RpoE-dependent (Sperandeo, 2007).

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BamHI EcoRI HindIII