GenePage for the patA gene of Escherichia coli K-12

Primary Gene Name: patA
EcoGene Accession Number: EG12718
K-12 Gene Accession Number: ECK3063
MG1655 Gene Identifier: b3073
Gene Name Mnemonic: Putrescine aminotransferase
Alternate Gene Symbols: ygjG
Description: Putrescine:2-oxoglutaric acid aminotransferase; putrescine aminotransferase
  # bp Upstream # bp Downstream
MW: 49661.37 ---------459 aa Pre-Run BlastP UniProt
Pre-Run BlastP NR+Env
Left End: 3219494
Left Intergenic Region

Name: aer_patA

Length: 417 bp gap

Orientation: Divergent

Left_end: 3219077

Right_end: 3219493

Centisome: 69.35

Genomic Address
Clockwise
Minute or Centisome (%) = 69.36
Right End: 3220873
Right Intergenic Region

Name: patA_ygjH

Length: 41 bp gap

Orientation: Convergent

Left_end: 3220874

Right_end: 3220914

Centisome: 69.39

PatA(YgjG) and PatD(Prr,YdcW) form an alternative to the Puu pathway converting putrescine to gamma-aminobutyric acid (Samsonova, 2005). PatA(YgjG) also transaminates cadaverine and spermidine. A mutation was isolated, mapped to 89' and named pat that has 10% of wildtype putrescine aminotransferase activity (Shaibe, 1985). To distinguish the original pat gene which has not yet been mapped to an ORF from the structural patA gene it is refered to as patB(pat); perhaps the patB(pat) mutation affects PAT activity either indirectly or as a regulator. patA(ygjG) is regulated by RpoN and RpoS (Schneider, 2013; Kim, 2014). The patA(ygjG)-aer divergent operon promoter region binds ArcA and ArcA represses patA(ygjG) expression (Federowicz, 2014).

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BamHI EcoRI HindIII