GenePage for the yqjA gene of Escherichia coli K-12

Primary Gene Name: yqjA
EcoGene Accession Number: EG12740
K-12 Gene Accession Number: ECK3086
MG1655 Gene Identifier: b3095
Gene Name Mnemonic: Systematic nomenclature
Alternate Gene Symbols: ecfL
Description: General envelope maintenance protein, DedA family protein; inner membrane protein
  # bp Upstream # bp Downstream
MW: 24585.49 ---------220 aa Pre-Run BlastP UniProt
Pre-Run BlastP NR+Env
Left End: 3247773
Left Intergenic Region

Name: exuR_yqjA

Length: 344 bp gap

Orientation: Codirectional+

Left_end: 3247429

Right_end: 3247772

Centisome: 69.96

Genomic Address
Clockwise
Minute or Centisome (%) = 69.97
Right End: 3248435
Right Intergenic Region

Name: yqjA_mzrA

Length: 3 bp gap

Orientation: Codirectional+

Left_end: 3248436

Right_end: 3248438

Centisome: 69.98

A yqjA yghB double mutant is sensitive to biocides and cationic compounds known to be exported by multidrug efflux transporters MdfA, EmrE and Acr; this hypersensitivity is exacerbated by mutations in mdfA, emrE and acrB; all double mutant phenotypes are suppressed by an mdfA clone; E39 and D51 of YqjA and YghB are required for complementation of the drug-sensitivity phenotypes (Kumar, 2014). One of the redundant function proteins YqjA or YghB is required for general envelope maintenance and for PMF homeostasis under various growth conditions (Sikdar, 2012). A yqjA yghB double mutant has a membrane defect causing a cell division defect at low temperatures and an osmoremedial growth defect at elevated temperatures (Thomkins, 2008). DedA superfamily proteins YqjA and YghB likely have redundant functions since only a double mutant has defects; DedA superfamily members yabI or yohD can complement the yqjA yghB double mutant when overproduced, but a dedA clone cannot complement (Thompkins, 2008). DedA family. A yqjA yghB double mutant is defective in the Tat-dependent export of AmiA and AmiC (Sikdar, 2009). A yqjA yghB double mutant is complemented by the sole dedA family gene in B. burgdorferi bb0250 (Liang, 2010). The E. coli K-12 DedA superfamily (SNARE associated Golgi protein/PF09335) has eight paralogs in two families, the COG0586 DedA/YghB family (including the DedA/YabI/YohD subfamily and the general envelope maintenance protein YghB/YqjA subfamily) and the YdjX family (including the COG0398 YdjX/YdjZ subfamily and the COG1238 YqaA subfamily) (Doerrler, 2013; K.E.R.).

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BamHI EcoRI HindIII