GenePage for the gspA gene of Escherichia coli K-12

Primary Gene Name: gspA
EcoGene Accession Number: EG12888
K-12 Gene Accession Number: ECK3310
MG1655 Gene Identifier: b3323
Gene Name Mnemonic: General secretory pathway
Alternate Gene Symbols: yheD
Description: Part of H-NS-silenced gsp-alpha (T2SS-alpha) divergent operons; type II protein secretion; cloned gsp-alpha (T2SS-alpha) divergent operons secretes ChiA, requires gspAB operon
  # bp Upstream # bp Downstream
MW: 55297.97 ---------489 aa Pre-Run BlastP UniProt
Pre-Run BlastP NR+Env
Left End: 3453929
Left Intergenic Region

Name: gspB_gspA

Length: 1 bp gap

Orientation: Codirectional-

Left_end: 3453928

Right_end: 3453928

Centisome: 74.41

Genomic Address
Counterclockwise
Minute or Centisome (%) = 74.41
Right End: 3455398
Right Intergenic Region

Name: gspA_gspC

Length: 179 bp gap

Orientation: Divergent

Left_end: 3455399

Right_end: 3455577

Centisome: 74.44

GspA is homologous to exeA of A. hydrophila, which is required for protein export, specifically for the export and assembly of secretin (ExeD/GspD) into the outer membrane. GspA has an N-terminal predicted cytoplasmic domain with an ATP/GTP binding motif, a single predicted transmembrane segment (239-261), followed by a predicted periplasmic domain with a predicted C-terminal peptidoglycan-binding motif (407-467; Pfam PG_binding_1). GspA may interact with GspB. A divergon is a regulon comprised of two adjacent divergent operons or genes. Overexpression causes a decrease in the amount of biofilm formed and decreases motility.

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BamHI EcoRI HindIII