GenePage for the nfuA gene of Escherichia coli K-12

Primary Gene Name: nfuA
EcoGene Accession Number: EG12935
K-12 Gene Accession Number: ECK3401
MG1655 Gene Identifier: b3414
Gene Name Mnemonic: NifU C-terminal domain-like
Alternate Gene Symbols: gntY; yhgI
Description: Fe/S biogenesis protein; possible scaffold/chaperone for damaged Fe/S proteins
  # bp Upstream # bp Downstream
MW: 20997.70 ---------191 aa Pre-Run BlastP UniProt
Pre-Run BlastP NR+Env
Left End: 3545624
Left Intergenic Region

Name: gntX_nfuA

Length: 58 bp gap

Orientation: Codirectional+

Left_end: 3545566

Right_end: 3545623

Centisome: 76.39

Genomic Address
Clockwise
Minute or Centisome (%) = 76.39
Right End: 3546199
Right Intergenic Region

Name: nfuA_gntT

Length: 359 bp gap

Orientation: Codirectional+

Left_end: 3546200

Right_end: 3546558

Centisome: 76.40

NfuA can transfer its [4Fe-4S] cluster into apo-aconitase AcnA and nfuA mutants have reduced survival to oxidative and iron stress (Angelini, 2008). nfuA(yhgI) is required for the utilization of DNA as a carbon source and is a H. influenzae competence protein ComG homolog (Palchevskiy, 2006). nfuA(gntY) does not have a role in gluconate metabolism (T.Conway, personal communication, 2000). iscA, sufA, and erpA are paralogs; nfuA is a possible HT gene with an N-terminal domain homologous to iscA and an additional thioredoxin-like C-terminal domain. IcsR regulon.

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BamHI EcoRI HindIII