GenePage for the queE gene of Escherichia coli K-12

Primary Gene Name: queE
EcoGene Accession Number: EG13034
K-12 Gene Accession Number: ECK2771
MG1655 Gene Identifier: b2777
Gene Name Mnemonic: Queuosine
Alternate Gene Symbols: ygcF
Description: 7-carboxy-7-deazaguanine synthase; queuosine biosynthesis
  # bp Upstream # bp Downstream
MW: 25029.65 ---------223 aa Pre-Run BlastP UniProt
Pre-Run BlastP NR+Env
Left End: 2904747
Left Intergenic Region

Name: ygcE_queE

Length: 1372 bp gap

Orientation: Convergent

Left_end: 2903375

Right_end: 2904746

Centisome: 62.55

Genomic Address
Counterclockwise
Minute or Centisome (%) = 62.58
Right End: 2905418
Right Intergenic Region

Name: queE_yqcG

Length: 138 bp gap

Orientation: Divergent

Left_end: 2905419

Right_end: 2905556

Centisome: 62.59

An E. coli queE(ygcF) mutant lacks quenosine and epoxyqueuosine (Miles, 2011). The orthologous B. subtilis QueE has been shown to have 7-carboxy-7-deazaguanine (CDG) synthatse activity in vitro; QueE converts 6-carboxy-5,6,7,8-tetrahydropterin (CPH(4) to CDG (McCarty, 2009). The B. subtilis ortholog is involved in queuosine preQ0 synthesis (Reader, 2004). Overexpression causes filamentous biofilm formation (Tenorio, 2003). Radical SAM superfamily.

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BamHI EcoRI HindIII