GenePage for the cptA gene of Escherichia coli K-12

Primary Gene Name: cptA
EcoGene Accession Number: EG13074
K-12 Gene Accession Number: ECK2891
MG1655 Gene Identifier: b2896
Gene Name Mnemonic: Cytoskeleton Polymerization-inhibiting Toxin
Alternate Gene Symbols: pigV(Serratia); ygfX
Description: Toxin of CptAB toxin-antitoxin pair
  # bp Upstream # bp Downstream
MW: 16064.02 ---------135 aa Pre-Run BlastP UniProt
Pre-Run BlastP NR+Env
Left End: 3040416
Left Intergenic Region

Name: fldB_cptA

Length: 39 bp gap

Orientation: Convergent

Left_end: 3040377

Right_end: 3040415

Centisome: 65.50

Genomic Address
Counterclockwise
Minute or Centisome (%) = 65.50
Right End: 3040823
Right Intergenic Region

Name: cptA_sdhE

Length: 20 bp overlap

Orientation: Codirectional-

Left_end: 3040804

Right_end: 3040823

Centisome: 65.51

E. coli CptA(YgfX) can complement a Serratia sdhE ygfX double mutant, restoring synthesis of the characteristic red tripyrrole pigment prodigiosin (Pig), and may have an unknown regulatory role in E. coli (McNeil, 2012). CptA has an N-terminal membrane domain and C-terminal cytoplasmic domain and CptA blocks growth when overproduced in vivo; the C-terminal CptA domain binds to and inhibits the polymerization of MreB and FtsZ in vitro; the mechanism for the apparent antitoxin activity of SdhE(CptB) during co-overproduction is unknown but SdhE(CptB) does not bind directly to CptA (Masuda, 2012). Although CptA is descibed as a toxin, it may actually be a toxic product, i.e. it is toxic when overproduced but serves an important non-toxin role when it is made at a tolerable level; it may be important to control the levels of toxic products in vivo and the apparent antitoxin activity of SdhE(CptB) may be a mechanism to limit CptB expression to avoid unwanted toxic effects, i.e. SdhE(CptB) co-expression has an anti-toxic effect, but SdhE(CptB) is not a true antitoxin (K.E.R.).

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BamHI EcoRI HindIII