GenePage for the yajL gene of Escherichia coli K-12

Primary Gene Name: yajL
EcoGene Accession Number: EG13272
K-12 Gene Accession Number: ECK0418
MG1655 Gene Identifier: b0424
Gene Name Mnemonic: Systematic nomenclature
Alternate Gene Symbols: thiJ
Description: Covalent chaperone for sulfenylated thiol proteins; confers resistance to oxidative stress, chaperone activity; mutant accumulates protein aggregates
  # bp Upstream # bp Downstream
MW: 20777.09 ---------196 aa Pre-Run BlastP UniProt
Pre-Run BlastP NR+Env
Left End: 443051
Left Intergenic Region

Name: thiI_yajL

Length: 53 bp gap

Orientation: Convergent

Left_end: 442998

Right_end: 443050

Centisome: 9.54

Genomic Address
Counterclockwise
Minute or Centisome (%) = 9.55
Right End: 443641
Right Intergenic Region

Name: yajL_panE

Length: 38 bp overlap

Orientation: Codirectional-

Left_end: 443604

Right_end: 443641

Centisome: 9.56

The YajL chaperone forms mixed disulfides with target proteins, preferentially at sulfenylated cysteines (Le, 2012; Gautier, 2012). YajL stimulates refolding of citrate cynthase in vitro, and a yajL mutant has increased protein aggregation during aerobiosis, is sensitive to oxidative stress, and has reduced mRNA levels for the aggregated proteins (Kthiri, 2010). YajL has been mistakenly described as ThiJ, involved in thiamine metabolism. This phenotype is now attributed to the adjacent thiI gene (T. Begley, personal communication cited in Mueller et al., NAR 26:2606-10 (1998). C56 peptidase family; DJ-1/PARK7 superfamily; PfpI/HchA protease/chaperone family.

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BamHI EcoRI HindIII