GenePage for the lpoB gene of Escherichia coli K-12

Primary Gene Name: lpoB
EcoGene Accession Number: EG13431
K-12 Gene Accession Number: ECK1091
MG1655 Gene Identifier: b1105
Gene Name Mnemonic: Lipoprotein activator of PBP from OM
Alternate Gene Symbols: ycfM
Description: OM lipoprotein stimulator of MrcB transpeptidase
  # bp Upstream # bp Downstream
MW: 22515.64 ---------213 aa Pre-Run BlastP UniProt
Pre-Run BlastP NR+Env
Left End: 1162638
Left Intergenic Region

Name: ycfL_lpoB

Length: 13 bp gap

Orientation: Codirectional+

Left_end: 1162625

Right_end: 1162637

Centisome: 25.05

Genomic Address
Clockwise
Minute or Centisome (%) = 25.05
Right End: 1163279
Right Intergenic Region

Name: lpoB_thiK

Length: 20 bp overlap

Orientation: Codirectional+

Left_end: 1163260

Right_end: 1163279

Centisome: 25.06

LpoB binds to and stimulates PBP1B (MrcB) to synthesize more peptidoglycan (murein) (Paradis-Bleau, 2010; Typas, 2010; Young, 2010). The PDB 4Q6Z structure the LpoB C-terminal domain is derived from E. coli UT189 but is 100% identical to K-12 LpoB (King, 2014). The LpoB-PBP1B complex may contribute to OM constriction during cell division (Typas, 2010). The first 19 aa of LpoB are a type II signal peptide. The TTG at codon -1 or the ATG at codon +4 could be the true start codon.

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BamHI EcoRI HindIII