GenePage for the yoaB gene of Escherichia coli K-12

Primary Gene Name: yoaB
EcoGene Accession Number: EG13514
K-12 Gene Accession Number: ECK1807
MG1655 Gene Identifier: b1809
Gene Name Mnemonic: Systematic nomenclature
Alternate Gene Symbols: None
Description: Putative reactive intermediate deaminase, UPF0076 family; reaction intermediate detoxification
  # bp Upstream # bp Downstream
MW: 12493.23 ---------114 aa Pre-Run BlastP UniProt
Pre-Run BlastP NR+Env
Left End: 1893367
Left Intergenic Region

Name: yoaA_yoaB

Length: 131 bp gap

Orientation: Divergent

Left_end: 1893236

Right_end: 1893366

Centisome: 40.79

Genomic Address
Clockwise
Minute or Centisome (%) = 40.79
Right End: 1893711
Right Intergenic Region

Name: yoaB_yoaC

Length: 421 bp gap

Orientation: Codirectional+

Left_end: 1893712

Right_end: 1894132

Centisome: 40.80

The Salmonella PF01042 family member RidA(YjgF) is an enamine/imine deaminase required for the detoxification of reactive intermediates of the PLP-dependent threonine dehydratase IlvA, releasing ammonia in a water-based reaction indicative of the low water environment of the cell (Lambrecht, 2012). RidA(YjgF), RutC, TdcF, YoaB and YjgH are paralogs and members of a highly conserved RidA(YjgF) family (pfam:PF01042) with diverse mutant phenotypes; the family members form homotrimers, some binding 2-ketoglutarate or related compounds, and all are probably reactive intermediate deaminases. The rat homolog PSP (perchloric acid-soluble protein) has been reported to have endoribonuclease activity, Endoribonuclease L, against ss mRNA, inhibiting translation.

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BamHI EcoRI HindIII