GenePage for the wzb gene of Escherichia coli K-12

Primary Gene Name: wzb
EcoGene Accession Number: EG13567
K-12 Gene Accession Number: ECK2055
MG1655 Gene Identifier: b2061
Gene Name Mnemonic: Systematic nomenclature
Alternate Gene Symbols: None
Description: Protein-tyrosine-phosphatase; required for extracellular colanic acid production; dephosphorylates Wzc-P; induced by AI-2 pheromone
  # bp Upstream # bp Downstream
MW: 16709.28 ---------147 aa Pre-Run BlastP UniProt
Pre-Run BlastP NR+Env
Left End: 2135655
Left Intergenic Region

Name: wzc_wzb

Length: 2 bp gap

Orientation: Codirectional-

Left_end: 2135653

Right_end: 2135654

Centisome: 46.01

Genomic Address
Counterclockwise
Minute or Centisome (%) = 46.01
Right End: 2136098
Right Intergenic Region

Name: wzb_wza

Length: 5 bp gap

Orientation: Codirectional-

Left_end: 2136099

Right_end: 2136103

Centisome: 46.02

Wzb activates colanic acid synthesis for capsule production by dephosphorylating the autokinased Wzc-P tyrosine-protein kinase (Vincent, 1999; Vincent, 2000; Grangeasse, 2002). Wzb also dephosphorylates Etp-P in vitro and the cryptic Etp phosphatase dephosphorylates Wzb-P in vitro (Vincent, 2000). Wzc belongs to the low molecular weight phosphotyrosine protein phosphatase (LMWPc) family (Pfam PF01451).

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BamHI EcoRI HindIII