GenePage for the prpE gene of Escherichia coli K-12

Primary Gene Name: prpE
EcoGene Accession Number: EG13604
K-12 Gene Accession Number: ECK0332
MG1655 Gene Identifier: b0335
Gene Name Mnemonic: Propionate
Alternate Gene Symbols: yahU
Description: Propionate-CoA ligase
  # bp Upstream # bp Downstream
MW: 69350.93 ---------628 aa Pre-Run BlastP UniProt
Pre-Run BlastP NR+Env
Left End: 352706
Left Intergenic Region

Name: prpD_prpE

Length: 39 bp gap

Orientation: Codirectional+

Left_end: 352667

Right_end: 352705

Centisome: 7.60

Genomic Address
Clockwise
Minute or Centisome (%) = 7.60
Right End: 354592
Right Intergenic Region

Name: prpE_codB

Length: 329 bp gap

Orientation: Codirectional+

Left_end: 354593

Right_end: 354921

Centisome: 7.64

prpE is in the prp operon for propionate catabolism via 2-methylcitrate cycle in Salmonella but a prpE mutant still grows well on propionate but prpE acs double mutants do not, indicating that acetyl-CoA synthase can substitute for prpE (Horswill, 1999b). Crp regulon.

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BamHI EcoRI HindIII