GenePage for the ybhK gene of Escherichia coli K-12

Primary Gene Name: ybhK
EcoGene Accession Number: EG13667
K-12 Gene Accession Number: ECK0769
MG1655 Gene Identifier: b0780
Gene Name Mnemonic: Systematic nomenclature
Alternate Gene Symbols: None
Description: Putative CofD superfamily transferase, function unknown; dimeric
  # bp Upstream # bp Downstream
MW: 32787.92 ---------302 aa Pre-Run BlastP UniProt
Pre-Run BlastP NR+Env
Left End: 815739
Left Intergenic Region

Name: uvrB_ybhK

Length: 191 bp gap

Orientation: Convergent

Left_end: 815548

Right_end: 815738

Centisome: 17.57

Genomic Address
Counterclockwise
Minute or Centisome (%) = 17.57
Right End: 816647
Right Intergenic Region

Name: ybhK_moaA

Length: 396 bp gap

Orientation: Divergent

Left_end: 816648

Right_end: 817043

Centisome: 17.59

E. coli YbhK partially complements a B. subtilis mgfK(yvcK) mutant; MgfK(YvcK) is required for morphogenesis via localization of PBP1 under gluconeogenic growth conditions, MgfK(YvcK) is organized as a helical cytoskeletal structure (Görke, 2005; Foulquier, 2011). Three global studies have identified YbhK as an FtsK-binding protein (Butland, 2005; Arifuzzaman, 2006; Hu, 2009). CofD proteins, 2-phospho-L-lactate transferases required for coenzyme F420 synthesis in methanogenic bacteria, and YcvK/YbhK proteins form two different clades of the CofD-YcvK superfamily; YcvK/YhbK proteins have altered substrate-binding pockets as compared to CofD but both sub-families may bind phosphate or phosphorylated substrates. The ybhK promoter region binds FNR and ArcA and ybhK expression is activated by ArcA (Federowicz, 2014).

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BamHI EcoRI HindIII