GenePage for the mdfA gene of Escherichia coli K-12

Primary Gene Name: mdfA
EcoGene Accession Number: EG13696
K-12 Gene Accession Number: ECK0832
MG1655 Gene Identifier: b0842
Gene Name Mnemonic: Multidrug facilitator
Alternate Gene Symbols: cmlA; cmr
Description: Transmembrane multidrug efflux transporter; confers alkaline pH tolerence
  # bp Upstream # bp Downstream
MW: 44320.93 ---------410 aa Pre-Run BlastP UniProt
Pre-Run BlastP NR+Env
Left End: 883673
Left Intergenic Region

Name: ybjG_mdfA

Length: 284 bp gap

Orientation: Divergent

Left_end: 883389

Right_end: 883672

Centisome: 19.03

Genomic Address
Clockwise
Minute or Centisome (%) = 19.04
Right End: 884905
Right Intergenic Region

Name: mdfA_ybjH

Length: 40 bp gap

Orientation: Convergent

Left_end: 884906

Right_end: 884945

Centisome: 19.06

Major Facilitator Superfamily (MFS). The C-terminal domain is not required for the function of MdfA. MdfA(Cmr) may also be an arabinose efflux transporter because an mdfA(cmr) mutant has increased intracellular arabinose, but not xylose; other compounds were not tested (Koita, 2012).

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BamHI EcoRI HindIII