GenePage for the etp gene of Escherichia coli K-12

Primary Gene Name: etp
EcoGene Accession Number: EG13727
K-12 Gene Accession Number: ECK0973
MG1655 Gene Identifier: b0982
Gene Name Mnemonic: E. coli phosphoTyrosine-protein Phosphatase
Alternate Gene Symbols: yccY
Description: Protein-tyrosine-phosphatase, required for O-antigen capsule formation; dephosphorylates Etk-P
  # bp Upstream # bp Downstream
MW: 16385.95 ---------148 aa Pre-Run BlastP UniProt
Pre-Run BlastP NR+Env
Left End: 1044230
Left Intergenic Region

Name: etk_etp

Length: 19 bp gap

Orientation: Codirectional-

Left_end: 1044211

Right_end: 1044229

Centisome: 22.50

Genomic Address
Counterclockwise
Minute or Centisome (%) = 22.50
Right End: 1044676
Right Intergenic Region

Name: etp_gfcE

Length: 13 bp overlap

Orientation: Codirectional-

Left_end: 1044664

Right_end: 1044676

Centisome: 22.51

E. coli K-12 Etk is de-phosphorylated by the Etp phosphatase in vitro (Vincent, 2000). E. coli K-12 does not produce O-antigen capsule polysaccharide because the cryptic gfcABCDE-etp-etk operon is silenced by IS1D in the promoter region (Peleg, 2005). Etp is required for O-antigen capsule formation in enteropathogenic E. coli (EPEC) (Peleg, 2005). Etp Y121 is phosphorylated by an unknown kinase, not Etk or Wzc, and can autodephosphorylate in vitro (Nadler, 2012). etp and wzb are paralogs. Etp can dephosphorylates Wzc-P and Wzb-P in vitro (Vincent, 2000). Etp belongs to the low molecular weight phosphotyrosine protein phosphatase (LMWPc) family (Pfam PF01451).

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BamHI EcoRI HindIII