GenePage for the pgaD gene of Escherichia coli K-12

Primary Gene Name: pgaD
EcoGene Accession Number: EG13862
K-12 Gene Accession Number: ECK1011
MG1655 Gene Identifier: b1021
Gene Name Mnemonic: Poly--1,6-N-acetyl-d-glucosamine
Alternate Gene Symbols: hmsS(Y.p.); ycdP
Description: Biofilm PGA synthase PgaCD, regulatory subunit; c-di-GMP-stimulated activity and dimerization
  # bp Upstream # bp Downstream
MW: 16081.75 ---------137 aa Pre-Run BlastP UniProt
Pre-Run BlastP NR+Env
Left End: 1086106
Left Intergenic Region

Name: phoH_pgaD

Length: 49 bp gap

Orientation: Convergent

Left_end: 1086057

Right_end: 1086105

Centisome: 23.40

Genomic Address
Counterclockwise
Minute or Centisome (%) = 23.40
Right End: 1086519
Right Intergenic Region

Name: pgaD_pgaC

Length: 1 bp gap

Orientation: Codirectional-

Left_end: 1086520

Right_end: 1086520

Centisome: 23.41

PgaC is the catalytic subunit of the inner membrane PgaCD poly-beta-1,6-N-acetyl-D-glucosamine synthase required for formation of the biofilm adhesin polysaccharide PGA by polymerizing and exporting cytoplasmic UDP-N-acetylglucosamine to the periplasm without a carrier protein; c-di-GMP binds allosterically to a pocket formed by PgaCD dimerization, stabilizing the PgaD regulatory subunit and activating PgaCD activity (Steiner, 2012). Full induction of pgaD requires c-di-GMP specifically produced by DgcZ(YdeH) (Boehm, 2009). pgaD complements a mutation in the homologous Y. pestis hemin storage gene hmsS. CsrA regulon. PGA, also known as PNAG, is poly-beta-1,6-N-acetyl-D-glucosamine.

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BamHI EcoRI HindIII