GenePage for the thiM gene of Escherichia coli K-12

Primary Gene Name: thiM
EcoGene Accession Number: EG14069
K-12 Gene Accession Number: ECK2097
MG1655 Gene Identifier: b2104
Gene Name Mnemonic: Thiamine (and thiazole)
Alternate Gene Symbols: None
Description: Hydroxyethylthiazole kinase
  # bp Upstream # bp Downstream
MW: 27339.16 ---------262 aa Pre-Run BlastP UniProt
Pre-Run BlastP NR+Env
Left End: 2184513
Left Intergenic Region

Name: thiD_thiM

Length: 4 bp overlap

Orientation: Codirectional-

Left_end: 2184513

Right_end: 2184516

Centisome: 47.06

Genomic Address
Counterclockwise
Minute or Centisome (%) = 47.06
Right End: 2185301
Right Intergenic Region

Name: thiM_rcnR

Length: 222 bp gap

Orientation: Codirectional-

Left_end: 2185302

Right_end: 2185523

Centisome: 47.08

thiMD operon expression is controlled by a thiamine pyrophosphate (TPP) responsive riboswitch in the 5' UTR. The thiM riboswitch is the target for the antibiotic pyrithiamine. The PDB links are to the structures of various thiM riboswitch/small molecule complexes: 2GDI, TPP; 2HOJ, TPP/Mn2+; 2HOK, TPP/Ca2+; 2HOL, TPP/Ba2+; 2HOM,TMP; 2HOO, BTP; 2HOP, PT (Serganov, 2006; Edwards, 2006).

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BamHI EcoRI HindIII