GenePage for the smrB gene of Escherichia coli K-12

Primary Gene Name: smrB
EcoGene Accession Number: EG14117
K-12 Gene Accession Number: ECK2325
MG1655 Gene Identifier: b2331
Gene Name Mnemonic: Small mutS2-related
Alternate Gene Symbols: yfcN
Description: Predicted DNA endonuclease, function unknown
  # bp Upstream # bp Downstream
MW: 21013.32 ---------183 aa Pre-Run BlastP UniProt
Pre-Run BlastP NR+Env
Left End: 2448606
Left Intergenic Region

Name: prmB_smrB

Length: 165 bp gap

Orientation: Divergent

Left_end: 2448441

Right_end: 2448605

Centisome: 52.75

Genomic Address
Clockwise
Minute or Centisome (%) = 52.75
Right End: 2449157
Right Intergenic Region

Name: smrB_yfcO

Length: 70 bp gap

Orientation: Convergent

Left_end: 2449158

Right_end: 2449227

Centisome: 52.76

SmrB homolog SmrA(YdaL) has DNA endonuclease activity (Gui, 2011). The two E. coli Smr proteins were identified and named smr based on homology to the C-terminal endonuclease domain of MutS2 which has an N-terminal domain homologous to MutS but MutS2 itself is not found in E. coli; mutS2 is usually found only in strains lacking smr genes (Moreira, 1999). Although the mnemonic for Smr is small mutS-related, mutS2-related is used since the Smr proteins do not have a region homologous to MutS itself.

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BamHI EcoRI HindIII