GenePage for the frc gene of Escherichia coli K-12

Primary Gene Name: frc
EcoGene Accession Number: EG14145
K-12 Gene Accession Number: ECK2370
MG1655 Gene Identifier: b2374
Gene Name Mnemonic: FoRmate CoA
Alternate Gene Symbols: yfdW
Description: Formyl CoA transferase, NAD(P)-binding; oxalate catabolism; dimeric
  # bp Upstream # bp Downstream
MW: 45828.18 ---------416 aa Pre-Run BlastP UniProt
Pre-Run BlastP NR+Env
Left End: 2492004
Left Intergenic Region

Name: oxc_frc

Length: 53 bp gap

Orientation: Codirectional-

Left_end: 2491951

Right_end: 2492003

Centisome: 53.69

Genomic Address
Counterclockwise
Minute or Centisome (%) = 53.69
Right End: 2493254
Right Intergenic Region

Name: frc_yfdX

Length: 512 bp gap

Orientation: Codirectional-

Left_end: 2493255

Right_end: 2493766

Centisome: 53.71

Orthologous to O. formigenes Frc. EvgAS regulon. The frc-oxc-yfdVE operon is adjacent and convergent on evgAS. Uninduced level is probably low since Sidhu et al. found no activity in E. coli host cells. Two monomers of Frc assemble as interlaced rings, defining the CoA binding site at their interface. Frc binds formyl-CoA and oxalate.

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BamHI EcoRI HindIII