GenePage for the sapA gene of Escherichia coli K-12

Primary Gene Name: sapA
EcoGene Accession Number: EG20254
K-12 Gene Accession Number: ECK1289
MG1655 Gene Identifier: b1294
Gene Name Mnemonic: Sensitivity to antimicrobial peptides
Alternate Gene Symbols: None
Description: Antimicrobial peptide ABC transporter periplasmic binding protein
  # bp Upstream # bp Downstream
MW: 61564.90 ---------547 aa Pre-Run BlastP UniProt
Pre-Run BlastP NR+Env
Left End: 1355467
Left Intergenic Region

Name: sapB_sapA

Length: 4 bp overlap

Orientation: Codirectional-

Left_end: 1355467

Right_end: 1355470

Centisome: 29.20

Genomic Address
Counterclockwise
Minute or Centisome (%) = 29.20
Right End: 1357110
Right Intergenic Region

Name: sapA_ymjA

Length: 312 bp gap

Orientation: Codirectional-

Left_end: 1357111

Right_end: 1357422

Centisome: 29.24

Characterized initially in Salmonella. The proposal that the sap operon transports peptides (Groisman, 1992) has been challenged (Stumpe, 1997; Harms, 2001). The first 21 aa of SapA are predicted to be a Type I signal peptide. A deletion mutant of Salmonella sapA was not as protamine-sensitive as sapD mutants (Parra-Lopez, 1993).

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BamHI EcoRI HindIII