GenePage for the folP gene of Escherichia coli K-12

Primary Gene Name: folP
EcoGene Accession Number: EG50011
K-12 Gene Accession Number: ECK3166
MG1655 Gene Identifier: b3177
Gene Name Mnemonic: Folate
Alternate Gene Symbols: dhpS
Description: Dihydropteroate synthase
  # bp Upstream # bp Downstream
Verified Start MW: 30615.11 ---------282 aa Pre-Run BlastP UniProt
Pre-Run BlastP NR+Env
Left End: 3324063
Left Intergenic Region

Name: glmM_folP

Length: 8 bp overlap

Orientation: Codirectional-

Left_end: 3324063

Right_end: 3324070

Centisome: 71.61

Genomic Address
Counterclockwise
Minute or Centisome (%) = 71.61
Right End: 3324911
Right Intergenic Region

Name: folP_ftsH

Length: 89 bp gap

Orientation: Codirectional-

Left_end: 3324912

Right_end: 3325000

Centisome: 71.63

folP insertion mutants grow in LB enriched with added folate (Gerdes, 2003). A folP deletion mutant grows very poorly in a rich medium unsupplemented by folate, although it is unclear if LB or 2X YT medium was used (Fermer, 1997). The folP mutants in the Keio collection have been shown to harbor an intact copy of folP in addition to the deletion allele (Yamamoto, 2009). The merodiploid folP duplication in the Keio mutants strains probably compensates for the lack of supplemental folate in the LB rich medium utilized to construct the folP mutants.

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BamHI EcoRI HindIII