EcoGene

GenePage for the thiB gene of Escherichia coli K-12

Primary Gene Name: thiB
EcoGene Accession Number: EG11574
K-12 Gene Accession Number: ECK0069
MG1655 Gene Identifier: b0068

Common Core

CommonCore-5

Extracellular Proteome

Periplasmic binding proteins, MalE family

thiB 5' UTR

ThiBPQ thiamine ABC transporter

Y-synonyms

Gene Name Mnemonic: Thiamin binding protein

Alternate Gene Symbols: sfuA, tbpA, yabL

Description:
Periplasmic thiamin binding protein; monomeric

Pre-Run BlastP UniProt

Protein Sequence: ------------ MW: 36163.41------327 aa ------------ Pre-Run BlastP NR+Env

Genomic Address
Left End: 74497 ----------------- Counterclockwise ----------------- Right End: 75480
Left Inter Gene Info Minute or Centisome (%) = 1.61 Right Inter Gene Info

PDF EcoMap

Curator or user-submitted Comments:

thiBPQ operon expression is controlled by a thiamine pyrophosphate (TPP) responsive riboswitch in the 128 nt 5' UTR. This THI element 5' UTR has been reported in intergenic sRNA searches as sroA/tpe79; the experimentally determined RNA start for sroA is used for the start of the BPQ mRNA. No new gene "sroA" is annotated in this regions since new sRNA genes must make stand-alone transscripts to be annotatd in EcoGene as sRNA genes. The thiB riboswitch is the target for the antibiotic pyrithiamine. The corrected U00096.2 sequence revises the sequence of the 18 aa ThiB signal peptide, previous thought to be 14 aa.