EcoGene

GenePage for the yaaW gene of Escherichia coli K-12

Primary Gene Name: yaaW
EcoGene Accession Number: EG14340
K-12 Gene Accession Number: ECK0011
MG1655 Gene Identifier: b0011

Horizontal Gene Transfer

HT1006

Y-genes

Gene Name Mnemonic: Systematic nomenclature

Alternate Gene Symbols: htgA, htpY

Description:
Conserved protein, UPF0174 family

Pre-Run BlastP UniProt

Protein Sequence: ------------ MW: 26664.88------237 aa ------------ Pre-Run BlastP NR+Env

Genomic Address
Left End: 10643 ----------------- Counterclockwise ----------------- Right End: 11356
Left Inter Gene Info Minute or Centisome (%) = 0.23 Right Inter Gene Info

PDF EcoMap

Curator or user-submitted Comments:

htgA was described as an an ORF on the opposite strand of yaaW, but the relationships among yaaW, htgA and htpY need to be reexamined. yaaW has homologs and looks like a protein-coding gene, whereas the ORF on the opposite strand once labeled htgA does not look like a protein coding gene. It is possible that there is a heat-inducible anti-sense regulatory RNA on the opposite strand of yaaW, but it is unlikely that this putative transcript would encode a functional protein product. A reexaminination shows no heat shock induction or Sigma 32 expression of htgA, consistent with it not being a gene or protein at all (Nonaka, 2006). Mutations in the opposite ORF would also disrupt yaaW and hence the htgA and htpY gene names are used as synonyms for yaaW. The experimental evidence supporting the existence of htgA is likely to be in error and the conclusions of Delaye (2008) regarding evolution of overlapping genes is unlikely to be true; their homology analysis and their analysis of substitutions within htgA are all consistent with htgA being an incorrect annotation; extreme skepticism is warranted when studying supposedly overlapping genes that do not appear to be phage-related in the E. coli chromsome.