Escherichia coli K-12 GenePage Master Page of dnaK
GenePage for the
dnaK
gene of
Escherichia coli
K-12
APEX: 13814.81
Bacteriome: dnaK
CDD-COG: COG0443
CGSC: CG844
ChemGen Gene Correlations: dnaK
ChemGen Growth Data: dnaK
CMR: P0A6Y8
Colibri: dnaK
COMBREX: 944750
DDBJ: AAC73125
Doodle: b0014
ECDC: CG00363
EchoBASE: EB0237
EchoLOCATION: EB0237
ECID: P0A6Y8
ECMDB: P0A6Y8
EcoliWiki: dnaK
eggNOG: P0A6Y8
EMBL: AAC73125
eSOL: JW0013
Gene-Profiles.org: dnaK
Genevestigator: P0A6Y8
GenExpDB: b0014
GenoBaseMG: b0014
Genome3D: P0A6Y8
GenomeReviews: P0A6Y8
GenPept-GenBank: AAC73125
GenPept-RefSeq: NP_414555.1
GenProtEC: b0014
GORBI: 944750
GREMLIN: P0A6Y8
iHOP: 944750
Inparanoid: NP_414555.1
iProClass: P0A6Y8
iRefWeb: 944750
Membranome: DNAK_ECOLI
MicrobesOnline: P0A6Y8
MiST: 1581307
ModBase: P0A6Y8
OMA: P0A6Y8
Orthology.org: 1
PairsDB: P0A6Y8
PATRIC: 32115121
PDB-UniProt: P0A6Y8
Pedant: 1128
PrFEct-Predict: dnaK
ProDom: P0A6Y8
ProteinOntology: 000022465
ProteinOntology: 000024933
ProteomeFolding at YRC: P0A6Y8
ProtMap_COG: COG0443#NC_000913
ProtoNet: P0A6Y8
QUARK: E11336
QuickGO: P0A6Y8
RegTransBase: 8798426
STRING: b0014
SWISS-2D: P0A6Y8
TCDB: P0A6Y8&tc=1.A.33.1.2
TCDB_Fam: 1.A.33
TF Binding Sites: dnaK.html
TIGR-CMR: NT01EC0015
Transimulation: b0014
Unison: P0A6Y8
wikigenes: 944750
WolframAlpha: dnaK
xbase-ColiBASE: b0014
Primary Gene Name:
dnaK
EcoGene Accession Number: EG10241
K-12 Gene Accession Number: ECK0014
MG1655 Gene Identifier:
b0014
APEX
AUG Start Codons
Biofilm Defective Mutants
Common Core
CommonCore-5
Curved Promoters
Cytosolic Proteome
Extracellular Proteome
Heat-stable Proteins
MIRAGE-Zn
Protein Lysine Acetylation: Yu, 2008
Total Proteome Lopez2005
Verified Set
Verified Translation Starts (+Met)
Verified Translation Starts Sites
[Pt(dien)(H2O)]2+
Gene Name Mnemonic: DNA
Alternate Gene Symbols: groPAB, groPC, groPF, grpC, grpF, seg
DNA Sequence
  # bp Upstream
# bp Downstream
Description:
Hsp70 molecular chaperone, heat-inducible; bichaperone with ClpB for protein disaggregation
Pre-Run BlastP UniProt
Protein Sequence
------------ MW: 69114.96------638 aa ------------
Pre-Run BlastP NR+Env
Genomic Address
Left End: 12163 ----------------- Clockwise ----------------- Right End: 14079
Left Inter Gene Info
Minute or Centisome (%) = 0.26
Right Inter Gene Info
 
gene or min(Cs)
PDF EcoMap
Curator or user-submitted Comments:
ClpB and DnaK cooperate (with DnaJ and GrpE) in the bichaperone-mediated, ATP-dependent unfolding of protein aggregates (Zolkiewski, 1999; Goloubinoff, 1999). DnaK mediates ATP-regulated binding and release of polypeptide substrates. Binds Zn(II). DnaJ is a co-chaperone for DnaK. Role in the initiation of DNA replication. DnaK has secondary amide peptide bond cis-trans isomerase (APIase) activity. A dnaK mutant is inviable above 42C, or below 8C (as enabled by transgenic Oleispira antarctica Cpn10/60). A tig dnaK double deletion is a synthetic lethal combination at 30 degrees C, however, no lethal effects are observed at 23 degrees C; overproduction of GroEL/GroES at 30 degrees C suppresses synthetic lethality. dnaK, hscA, hscC and yegD are paralogs. After four hours of Zn(II) stress, protein levels increased (Easton, 2006). DnaK lysines K70, K245, K246, K304, K359, K502, K528 and K587 can be modified to N6-succinyllysine (Zhang, 2011). DnaK lysines K109, K245, K304, K421, K556 and K577 can be modified to N6-acetyllysine (Yu, 2008; Zhang, 2009). HT_Cmplx22_Cyt: DnaK+GrpE+GyrA+RpsA. HT_Cmplx30_Mem: ClpB+DnaK+InfB+RpsA.
Copyright 2006 University of Miami.
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