EcoGene

GenePage for the mreB gene of Escherichia coli K-12

Bacteriome: mreB

ChemGen Gene Correlations: mreB

ChemGen Growth Data: mreB

Gene-Profiles.org: mreB

Genevestigator: P0A9X4

GenExpDB: b3251

Genome3D: P0A9X4

GenomeReviews: P0A9X4

GenPept: NP_417717.2

GenPept-GenBank: AAC76283

MicrobesOnline: P0A9X4

ProteinOntology: 000023289

ProteomeFolding at YRC: P0A9X4

TF Binding Sites: mreB.html

xbase-ColiBASE: b3251

Primary Gene Name: mreB
EcoGene Accession Number: EG10608
K-12 Gene Accession Number: ECK3239
MG1655 Gene Identifier: b3251

Verified Translation Starts (no Met)

Verified Translation Starts Sites

Gene Name Mnemonic: Murein cluster e; mecillinam resistance

Alternate Gene Symbols: envB, mon, rodY

Description:
Cell wall structural actin-like protein in MreBCD complex; mecillinam resistance protein

Pre-Run BlastP UniProt

Protein Sequence ------------ MW: 36952.40------347 aa ------------ Pre-Run BlastP NR+Env

Genomic Address
Left End: 3398066 ----------------- Counterclockwise ----------------- Right End: 3399109
Left Inter Gene Info Minute or Centisome (%) = 73.24 Right Inter Gene Info

PDF EcoMap

Curator or user-submitted Comments:

The cytoskeletal helical structure of MreB is reported to be an artifact of YFP labeling (Swulius, 2012). Overexpression causes abnormal biofilm architecture, reduces motility and inhibits cell division. mreB is in an operon with mreCD and the Mre gene products form an essential membrane-bound complex responsible for cell morphology. Perhaps relevant to the controversial sitution in E. coli, in B. subtilis EF-Tu is found in a static helical structure at the inner face of the cytoplasmic membrane co-localized with MreB; MreB and EF-Tu interact in vivo and in vitro; reduction of intracellular EF-Tu affects cell shape but not translation efficiency; EF-Tu intracellular protofilaments may serve as tracks for dynamic MreB shape-determining filaments (Defeu, 2010). Binds TrxA (Kumar, 2004).