EcoGene

GenePage for the rplK gene of Escherichia coli K-12

ChemGen Gene Correlations: rplK

ChemGen Growth Data: rplK

Gene-Profiles.org: rplK

Genevestigator: P0A7J7

GenExpDB: b3983

GenoBaseMG: b3983

Genome3D: P0A7J7

GenomeReviews: P0A7J7

GenPept-GenBank: AAC76957

GenPept-RefSeq: NP_418410.1

Inparanoid: NP_418410.1

iProClass: P0A7J7

iRefWeb: 948484

Membranome: RL11_ECOLI

MicrobesOnline: P0A7J7

Predicted Regulons: O4574

PrFEct-Predict: rplK

ProDom: P0A7J7

ProteinOntology: 000023817

ProteomeFolding at YRC: P0A7J7

ProtMap_COG: COG0080#NC_000913

ProtoNet: P0A7J7

QUARK: E10320

QuickGO: P0A7J7

RegulonDB-TU: ECK120016992

STRING: b3983

SWISS-2D: P0A7J7

TF Binding Sites: rplK.html

TIGR-CMR: NT01EC4842

Transimulation: b3983

Unison: P0A7J7

wikigenes: 948484

WolframAlpha: rplK

xbase-ColiBASE: b3983

Primary Gene Name: rplK
EcoGene Accession Number: EG10872
K-12 Gene Accession Number: ECK3974
MG1655 Gene Identifier: b3983

34 Active Assayable Promoters

Large Ribosomal proteins

Predicted Regulons McCue 2002

Ribosomal Proteins

Verified Set

Verified Translation Starts (+Met)

Verified Translation Starts Sites

Gene Name Mnemonic: Ribosomal protein, large

Alternate Gene Symbols: relC

Description:
50S ribosomal subunit protein L11; kasugamycin sensitivity

Pre-Run BlastP UniProt

Protein Sequence ------------ MW: 14875.38------142 aa ------------ Pre-Run BlastP NR+Env

Genomic Address
Left End: 4178447 ----------------- Clockwise ----------------- Right End: 4178875
Left Inter Gene Info Minute or Centisome (%) = 90.06 Right Inter Gene Info

PDF EcoMap

Curator or user-submitted Comments:

rplK is non-essential (Stöffler, 1980; Stöffler, 1981; van Dyke, 2003). rplK null mutants grow slowly, exhibiting high-temperature lethality and UAG suppression (van Dyke, 2003). The relC allele of rplK has a relaxed phenotype (Friesen, 1974; Parker, 1976). RplK has three residues trimethylated by the non-essential PrmA methyltransferase forming a blocking N-terminal N,N,N-trimethylalanine at residue A2 and forming two N6,N6,N6-trimethyllysines at residues K4 and K40 (Chang, 1975; Lederer, 1977; Dognin, 1980; Jerez, 1980; Vanet, 1994; Arnold, 1999). RplK lysines K72 and K81 can be modified to N6-succinyllysine (Zhang, 2011). Probably due to the slow growth phenotype of rplK mutations, the rplK mutants in the Keio collection have been shown to harbor an intact copy of rplK in addition to the deletion allele (Yamamoto, 2009).