EcoGene

GenePage for the entH gene of Escherichia coli K-12

Bacteriome: entH

CDD-COG: COG2050

CGSC: CG34776

ChemGen Gene Correlations: entH

ChemGen Growth Data: entH

Gene-Profiles.org: entH

Genevestigator: P0A8Y8

GenExpDB: b0597

GenoBaseMG: b0597

Genome3D: P0A8Y8

GenomeReviews: P0A8Y8

GenPept-GenBank: AAC73698

GenPept-RefSeq: NP_415129.1

Inparanoid: NP_415129.1

iProClass: P0A8Y8

iRefWeb: 945215

Membranome: YBDB_ECOLI

MicrobesOnline: P0A8Y8

ProteomeFolding at YRC: P0A8Y8

ProtMap_COG: COG2050#NC_000913

Transimulation: b0597

Unison: P0A8Y8

wikigenes: 945215

WolframAlpha: entH

xbase-ColiBASE: b0597

Primary Gene Name: entH
EcoGene Accession Number: EG11105
K-12 Gene Accession Number: ECK0590
MG1655 Gene Identifier: b0597

Gene Name Mnemonic: Enterochelin

Alternate Gene Symbols: ybdB

Description:
Enterobactin synthesis proofreading thioesterase

Pre-Run BlastP UniProt

Protein Sequence ------------ MW: 14970.10------137 aa ------------ Pre-Run BlastP NR+Env

Genomic Address
Left End: 629300 ----------------- Clockwise ----------------- Right End: 629713
Left Inter Gene Info Minute or Centisome (%) = 13.56 Right Inter Gene Info

PDF EcoMap

Curator or user-submitted Comments:

EntH corrects misacylation of the aryl carrier protein domain of EntB (Guo, 2009; Chen, 2009). EntH is a member of the HotDog superfamily of thioesterases and dehydratases (Pfam CL0050, PF03061; PDB 1VH9) (Dillon, 2004; Badger, 2005). EntH has acyl-CoA esterase activity in vitro (Kuznetsova, 2005). EntH has low level DHNA-CoA thioesterase activity but entH still mutants synthesize enterobactin (Chen, 2013). In addition to its role in iron acquisition, enterobactin plays a role in oxidative stress protection and is required to form colonies on M9 minimal media aerobically (Adler, 2014).