EcoGene

GenePage for the glmS gene of Escherichia coli K-12

APEX: 1408.22

Bacteriome: glmS

ChemGen Gene Correlations: glmS

ChemGen Growth Data: glmS

Gene-Profiles.org: glmS

Genevestigator: P17169

GenExpDB: b3729

Genome3D: P17169

GenomeReviews: P17169

GenPept: NP_418185.1

GenPept-GenBank: AAC76752

MicrobesOnline: P17169

ProteinOntology: 000022781

ProteomeFolding at YRC: P17169

ProtoNet: P17169

QuickGO: P17169

RegulonDB-TU: ECK120014524

STRING: P17169

SWISS-2D: P17169

TF Binding Sites: glmS.html

xbase-ColiBASE: b3729

Primary Gene Name: glmS
EcoGene Accession Number: EG10382
K-12 Gene Accession Number: ECK3722
MG1655 Gene Identifier: b3729

APEX

C44 Family Peptidases

Oxidized Proteins, Carbon

Oxidized Proteins, Nitrogen

Peptidase Families

Verified Set

Verified Translation Starts (+Met)

Verified Translation Starts Sites

Gene Name Mnemonic: Glucosamine

Alternate Gene Symbols: None

Description:
Glucosamine-6-phosphate synthase; glucosamine--fructose-6-phosphate aminotransferase; C-terminal F6P-binding domain has isomerase activity

Pre-Run BlastP UniProt

Protein Sequence ------------ MW: 66894.34------609 aa ------------ Pre-Run BlastP NR+Env

Genomic Address
Left End: 3909862 ----------------- Counterclockwise ----------------- Right End: 3911691
Left Inter Gene Info Minute or Centisome (%) = 84.27 Right Inter Gene Info

PDF EcoMap

Curator or user-submitted Comments:

YhbJ(RapZ) is an adaptor protein that recruits GlmZ to the catalytic domain of RNase E; GlmY is an anti-adaptor decoy sRNA that binds YhbJ(RapZ) competitively with GlmZ, protecting it from degradation (Göpel, 2013). GlmS synthesis is negatively feedback regulated by glucosamine-6-phosphate, and YhbJ(RapZ) enables degradation the GlmZ sRNA; unprocessed GlmZ upregulates glmS mRNA post-translationally by mediating an RNase E cleavage of the glmS mRNA (Kalamorz, 2007). The GlmY sRNA upregulates glmS post-transcriptionally (Urban, 2007). GlmS can be inactivated by various halomethyl and methyl ketone derivatives, of which bromomethyl ketone derivative is most effective because of its high binding affinity.