EcoGene

GenePage for the spoT gene of Escherichia coli K-12

Bacteriome: spoT

ChemGen Gene Correlations: spoT

ChemGen Growth Data: spoT

Gene-Profiles.org: spoT

Genevestigator: P0AG24

GenExpDB: b3650

Genome3D: P0AG24

GenomeReviews: P0AG24

GenPept: NP_418107.1

GenPept-GenBank: AAC76674

MicrobesOnline: P0AG24

ProteinOntology: 000023977

ProteomeFolding at YRC: P0AG24

ProtoNet: P0AG24

QuickGO: P0AG24

RegulonDB-TU: ECK120014633

xbase-ColiBASE: b3650

Primary Gene Name: spoT
EcoGene Accession Number: EG10966
K-12 Gene Accession Number: ECK3640
MG1655 Gene Identifier: b3650

Common Core

CommonCore-5

Essential Genes

Glycogen-deficiency ASKA clones

Stringent response and growth rate control

Gene Name Mnemonic: Spot (magic spot)

Alternate Gene Symbols: None

Description:
ppGpp 3'-pyrophosphohydrolase and ppGpp synthase II; guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase

Pre-Run BlastP UniProt

Protein Sequence ------------ MW: 79342.44------702 aa ------------ Pre-Run BlastP NR+Env

Genomic Address
Left End: 3820423 ----------------- Clockwise ----------------- Right End: 3822531
Left Inter Gene Info Minute or Centisome (%) = 82.34 Right Inter Gene Info

PDF EcoMap

Curator or user-submitted Comments:

ObgE(CgtA) binds SpoT and pre-50S ribosomes, ObgE(CgtA) increases ppGpp degradation by pre-50S ribosome-associated SpoT, and an obgE(cgtA) mutant has an elevated ppGpp level during growth, but not during the RelA-dependent stringent response (Jiang, 2007).