EcoGene

GenePage for the ftsH gene of Escherichia coli K-12

Bacteriome: ftsH

CDD-COG: COG0465

CGSC: CG735

ChemGen Gene Correlations: ftsH

ChemGen Growth Data: ftsH

Gene-Profiles.org: ftsH

Genevestigator: P0AAI3

GenExpDB: b3178

GenoBaseMG: b3178

Genome3D: P0AAI3

GenomeReviews: P0AAI3

GenPept-GenBank: AAC76210

GenPept-RefSeq: NP_417645.1

Inparanoid: NP_417645.1

iProClass: P0AAI3

iRefWeb: 947690

Membranome: FTSH_ECOLI

MEROPS: M41.001

MicrobesOnline: P0AAI3

Predicted Regulons: E4028

PrFEct-Predict: ftsH

ProDom: P0AAI3

ProteinOntology: 000022717

ProteomeFolding at YRC: P0AAI3

ProtMap_COG: COG0465#NC_000913

TF Binding Sites: hflB.html

Transimulation: b3178

Unison: P0AAI3

wikigenes: 947690

WolframAlpha: ftsH

xbase-ColiBASE: b3178

Primary Gene Name: ftsH
EcoGene Accession Number: EG11506
K-12 Gene Accession Number: ECK3167
MG1655 Gene Identifier: b3178

M41 Family Peptidases

Metallo Peptidases

OM Proteome Lopez2005

Peptidase Families

Predicted Regulons McCue 2002

Protein Lysine Acetylation: Yu, 2008

Total Proteome Lopez2005

Gene Name Mnemonic: Filamentation, temperature sensitive

Alternate Gene Symbols: hflB, mrsC, std, tolZ

Description:
ATP-dependent membrane protease, complexed with HflCK; regulates lysogeny; mutants are defective in cell growth, septum formation and phage lambda development; mutants rescued by divalent cations; binds Zn(II); hexameric

Pre-Run BlastP UniProt

Protein Sequence ------------ MW: 70708.09------644 aa ------------ Pre-Run BlastP NR+Env

Genomic Address
Left End: 3325001 ----------------- Counterclockwise ----------------- Right End: 3326935
Left Inter Gene Info Minute or Centisome (%) = 71.66 Right Inter Gene Info

PDF EcoMap

Curator or user-submitted Comments:

HtpX collaborates with FtsH to eliminate abnormal membrane proteins: an hflX ftsH double mutant is temperature sensitive for growth. FtsH degrades both cytoplasmic, e.g. phage lambda cII protein, and membrane, e.g. SecY, substrates.