EcoGene

GenePage for the wrbA gene of Escherichia coli K-12

Bacteriome: wrbA

CDD-COG: COG0655

CGSC: CG31836

ChemGen Gene Correlations: wrbA

ChemGen Growth Data: wrbA

Gene-Profiles.org: wrbA

Genevestigator: P0A8G6

GenExpDB: b1004

GenoBaseMG: b1004

Genome3D: P0A8G6

GenomeReviews: P0A8G6

GenPept-GenBank: AAC74089

GenPept-RefSeq: NP_415524.1

Inparanoid: NP_415524.1

iProClass: P0A8G6

iRefWeb: 947263

Membranome: WRBA_ECOLI

MicrobesOnline: P0A8G6

ProteinOntology: 000024221

ProteinOntology: 000025165

ProteomeFolding at YRC: P0A8G6

ProtMap_COG: COG0655#NC_000913

TF Binding Sites: wrbA.html

TIGR-CMR: NT01EC1225

Transimulation: b1004

Unison: P0A8G6

wikigenes: 947263

WolframAlpha: wrbA

xbase-ColiBASE: b1004

Primary Gene Name: wrbA
EcoGene Accession Number: EG11540
K-12 Gene Accession Number: ECK0995
MG1655 Gene Identifier: b1004

Oxidized Proteins, Carbon

Total Proteome Lopez2005

Verified Set

Verified Translation Starts (+Met)

Verified Translation Starts Sites

Gene Name Mnemonic: W(Trp) repressor binding

Alternate Gene Symbols: None

Description:
NAD(P)H:quinone oxidoreductase, type IV NQO; may protect against oxidative stress; dimeric, binds one FMN per monomer

Pre-Run BlastP UniProt

Protein Sequence ------------ MW: 20845.56------198 aa ------------ Pre-Run BlastP NR+Env

Genomic Address
Left End: 1067112 ----------------- Counterclockwise ----------------- Right End: 1067708
Left Inter Gene Info Minute or Centisome (%) = 23.00 Right Inter Gene Info

PDF EcoMap

Curator or user-submitted Comments:

WrbA was originally identified as a stationary phase TrpR-binding protein that affected the interaction of TrpR with its operator sites in vitro (Yang, 1993). However, subsequent experiments found similar effects with BSA, concluding that WrbA does not influence TrpR-operator binding in vitro (Grandori, 1998). Although WrbA may affect the association between Trp repressor and operators in stationary phase in vivo (Yang, 1993), this may be a non-specific effect. EcoArray search results indicate that wrbA transcripts are altered by rpoS, relA, trpA and trpR mutations, among others. wrbA is repressed by OxyS overexpression (Tjaden, 2006). otherPDB: 1ZWL(P.aeruginosa).