EcoGene

GenePage for the gpmA gene of Escherichia coli K-12

APEX: 4871.93

Bacteriome: gpmA

ChemGen Gene Correlations: gpmA

ChemGen Growth Data: gpmA

Gene-Profiles.org: gpmA

Genevestigator: P62707

GenExpDB: b0755

Genome3D: P62707

GenomeReviews: P62707

GenPept: NP_415276.1

GenPept-GenBank: AAC73842

MicrobesOnline: P62707

ProteinOntology: 000022830

ProteinOntology: 000025131

ProteomeFolding at YRC: P62707

ProtoNet: P62707

QuickGO: P62707

RegTransBase: 8801755

STRING: P62707

SWISS-2D: P62707

TF Binding Sites: gpmA.html

xbase-ColiBASE: b0755

Primary Gene Name: gpmA
EcoGene Accession Number: EG11699
K-12 Gene Accession Number: ECK0744
MG1655 Gene Identifier: b0755

APEX

Common Core

CommonCore-5

Predicted Regulons McCue 2002

Protein Lysine Acetylation: Yu, 2008

Verified Set

Verified Translation Starts (+Met)

Verified Translation Starts Sites

Gene Name Mnemonic: Glycerol P mutase

Alternate Gene Symbols: gpm

Description:
Phosphoglycerate mutase, 2,3-bisphosphoglycerate-dependent; dPGM; Fur regulon; dimeric

Pre-Run BlastP UniProt

Protein Sequence ------------ MW: 28556.40------250 aa ------------ Pre-Run BlastP NR+Env

Genomic Address
Left End: 786066 ----------------- Counterclockwise ----------------- Right End: 786818
Left Inter Gene Info Minute or Centisome (%) = 16.94 Right Inter Gene Info

PDF EcoMap

Curator or user-submitted Comments:

Purified GpmA has 10-20 times higher specific actvity than GpmM (Fraser, 1999; Foster, 2010). gpmA mutants exhibit a long lag when overnight minimal medium-grown cells are plated on rich medium; gpmA or gpmM clones rescued the defect (Foster, 2010). GpmA does not have phosphatase activity against para-nitrophenyl phosphate (Foster, 2010). gpmM and gpmA are non-essential genes but phosphoglycerate mutase is an essential enzyme since a gpmA gpmM double mutation is lethal (Foster, 2010). GpmA is a member of the histidine phosphatase superfamily, represented by the InterPro superfamily profile IPR013078 and CDD cl11399 (also called the dPGM superfamily) including phosphatases and fructose 2,6-bisphosphatases as well as factor-dependent phosphoglycerate mutases; the histidine phosphatase superfamily is characterized by a conserved histidine that is transiently phosphorylated during the catalytic cycle (Fothergill-Gilmore, 1989; Fothergill-Gilmore, 1990; Jedrzejas, 2000; Johnsen, 2007; Rigden, 2008; Foster, 2010). HT_Cmplx25_Cyt: GpmA+GpmM.