EcoGene

GenePage for the hypT gene of Escherichia coli K-12

Bacteriome: hypT

CDD-COG: COG0583

ChemGen Gene Correlations: hypT

ChemGen Growth Data: hypT

Gene-Profiles.org: hypT

Genevestigator: P39376

GenExpDB: b4327

GenoBaseMG: b4327

Genome3D: P39376

GenomeReviews: P39376

GenPept-GenBank: AAC77283

GenPept-RefSeq: NP_418747.1

Inparanoid: NP_418747.1

iProClass: P39376

iRefWeb: 948852

MicrobesOnline: P39376

ProteomeFolding at YRC: P39376

ProtMap_COG: COG0583#NC_000913

TF Binding Sites: yjiE.html

TIGR-CMR: NT01EC5303

Transimulation: b4327

Unison: P39376

wikigenes: 948852

WolframAlpha: hypT

xbase-ColiBASE: b4327

Primary Gene Name: hypT
EcoGene Accession Number: EG12566
K-12 Gene Accession Number: ECK4318
MG1655 Gene Identifier: b4327

AUG Start Codons

Common Core

CommonCore-5

LysR Transcriptional Regulator Family

Y-genes

Gene Name Mnemonic: Hypochlorite-responsive transcription factor

Alternate Gene Symbols: qseD, yjiE

Description:
Hypochlorite-responsive transcription factor

Pre-Run BlastP UniProt

Protein Sequence ------------ MW: 34710.72------303 aa ------------ Pre-Run BlastP NR+Env

Genomic Address
Left End: 4557378 ----------------- Counterclockwise ----------------- Right End: 4558289
Left Inter Gene Info Minute or Centisome (%) = 98.23 Right Inter Gene Info

PDF EcoMap

Curator or user-submitted Comments:

Three HypT(YjiE) methionine residues are converted to methionine sulfoxides by HOCl, activating HypT as a transcription factor; MsrA and MsrB inactivate HypT (Dazic, 2013). hypT(yjiE) mutants are sensitive to HOCl and yjiE plasmids confer HOCl resistance (Gebendorfer, 2012). HypT(YjiE) is a global regulator responding to HOCl exposure that replenishes methionine and cysteine pools and down-regulates genes involved in iron acquisition (Gebendorfer, 2012). HypT(YjiE) forms a variety of oligomers including dimers, tetramers and hexamers (Gebendorfer, 2012). The identification of YjiE as a motility regulator has been challenged as subsequently no effects of HypT(YjiE) on motility were observed (Gebendorfer, 2012). HypT(YjiE) is a LysR-type transcriptional regulator. HypT(YjiE) was initially identified as a cell density-dependent motility repressor.