EcoGene

GenePage for the ycdT gene of Escherichia coli K-12

Bacteriome: ycdT

ChemGen Gene Correlations: ycdT

ChemGen Growth Data: ycdT

Gene-Profiles.org: ycdT

Genevestigator: P75908

GenExpDB: b1025

Genome3D: P75908

GenomeReviews: P75908

GenPept: NP_415544.1

GenPept-GenBank: AAC74110

MicrobesOnline: P75908

ProteomeFolding at YRC: P75908

xbase-ColiBASE: b1025

Primary Gene Name: ycdT
EcoGene Accession Number: EG13866
K-12 Gene Accession Number: ECK1015
MG1655 Gene Identifier: b1025

Gene Name Mnemonic: Systematic nomenclature

Alternate Gene Symbols: None

Description:
Diguanylate cyclase, membrane-anchored

Pre-Run BlastP UniProt

Protein Sequence ------------ MW: 51782.53------452 aa ------------ Pre-Run BlastP NR+Env

Genomic Address
Left End: 1092099 ----------------- Clockwise ----------------- Right End: 1093457
Left Inter Gene Info Minute or Centisome (%) = 23.54 Right Inter Gene Info

PDF EcoMap

Curator or user-submitted Comments:

YcdT mRNA is translationally repressed by CsrA (Jonas, 2008). ycdT overexpression causes a 20-fold increase in c-di-GMP and represses motility, but a mutant has little effect (Jonas, 2008). The results of Jonas (2008) might indicate that although the c-di-GMP spike inhibits motility it is not known if this is the normal function of the overproduced diguanylate cyclase or if the overexpression induced non-physiological crosstalk. YcdT is homologous to Y. pestis hemin storage gene hmsT, but is unable to complement hmsT mutations. YcdT has been shown not to be a regulator of the divergent pgaABCD operon. Codon usage indicates ycdT is an alien (horizontal) gene. YcdT has an N-terminal integral membrane domain with 8 predicted TM helices reminiscent of the MASE TM signaling domains in other c-di-GMP enzymes. YcdT has a C-terminal diguanylate cyclase GGDEF domain.