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EcogeneTopic Page

TopicPage for DNA Replication of Escherichia coli K-12

Chromosome Metabolism         


Bidirectional DNA replication forks of the E. coli chromosome (2) initiate at oriC, (2) elongate convergently on sister chromophores, (3) assist in repair and recombination functions, (4) occassionally stall, (5) cross unidirection pause sites Ter A-F, and finally terminate at the intergene dif locus, where daughter chromsomes decatenate and separate.


At fast growth rates, multiple forks can be replicating the same DNA molecule simultaneously, in staged pairs.

The terminus region is dispensible and E. coli can replicate its chromsome as a linear molecule (Cui, 2007).

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