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TopicPage for Cisplatin Targets of Escherichia coli K-12

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Mass Spectrometry         
        

Description:

Will (2000) reported the identification of 31 E. coli Pt(II) binding proteins that bind the DNA-reactive anti-cancer drug cisplatin (cis-[PtCl(2)(NH(3))(2)]) using Multidimensional protein technology (MudPIT) LC/LC/MS/MS.

Details:

Will (2000) used BL21 not K-12 cells and identified an F factor gene finQ (P18809) and a P1 gene rep5 (P24042) not in K-12 and not in EcoGene so there are 29, not 31, genes in this topic.

Will (2000) also identified seven Pt(II) binding protein targets for [Pt(dien)(H2O)]2+.

Asp, Glt and Met residues are the predominant targets for cisplatin and the only targets for [Pt(dien)(H2O)]2+.


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