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TopicPage for Predicted Operons of Escherichia coli K-12


Operon         
        

Description:

Predicted operons usually have no experimental evidence other than microarray data that they are co-transcribed in a single transcription unit.

Microarray data and a variety of algorithms and have been used to predict operons for the entire genome, but this does not eliminate the need for experimental verification or heuristic individual case considerations.

Details:

The best predicted operons come from the integration of information derived from multivariable sources including (1) targeted in-house experimental verifications, (2) literature surveys and data indexing, (3) the integration of co-expression experimental results, (4) correlation of web- or paper-published computational predictions, and (4) expert curator case-by-case heuristics.


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