TopicPage for Predicted Operons of Escherichia coli K-12
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Predicted operons usually have no experimental evidence other than microarray data that they are co-transcribed in a single transcription unit.
Microarray data and a variety of algorithms and have been used to predict operons for the entire genome,
but this does not eliminate the need for experimental verification or heuristic individual case considerations.
The best predicted operons come from the integration of information derived from multivariable sources including (1) targeted in-house experimental verifications, (2) literature surveys and data indexing, (3) the integration of co-expression experimental results, (4) correlation of web- or paper-published computational predictions, and (4) expert curator case-by-case heuristics.
Bibliography (19 total) : Review Only   Up
Wang S, Wang Y, Du W, Sun F, Wang X, Zhou C, Liang Y (2007) A multi-approaches-guided genetic algorithm with application to operon prediction. Artif Intell Med 41:151-9
Dam P, Olman V, Harris K, Su Z, Xu Y (2007) Operon prediction using both genome-specific and general genomic information. Nucleic Acids Res 35:288-98