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TopicPage for Sigma 54 Regulons of Escherichia coli K-12



Sigma 54, the rpoN gene product, binds to core enzyme to form a holoenzyme capable of responding to a variety of different stresses including nitrogen starvation and membrane stress.


Sigma 54 requires response-specific activating Bacterial Enhancer Binding Proteins (bEBP) such as GlnG(NtrC),which is also a response regulator of a two-component system, with GlnL(NtrB) and PspF. Studies have been done to define these various regulons and they will be organized into a set here.

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