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EcogeneTopic Page
TopicPage for ABC transporter permeases of Escherichia coli K-12
 | ABC (ATP-Binding Cassette) Transporters |
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Description:
76 ATP-binding cassette (ABC) transporter system integral membrane permeases (known and predicted) are found in E. coli K-12. They are mostly defined by the 50 members in the Pfam PF00528 family. An additional 6 permeases are added from the PF1032(FecCD)[COG0609, COG4139, COG4779] family: FecC, FecD, FepD, BtuC, FhuB, FepG; 4 permeases are from the PF01061/COG0842 (ABC2_membrane) family: YadH, YbhR, YbhS, YhhJ; 6 are permease/ATP-binding fusion proteins: MdlA, MdlB, MsbA (COG1132); CydC (COG4987); CydD (COG4988); YojI (COG4615). RbbA is homologous to permease/ATP-binding fusion proteins (COG1123).
ABC transporters are conserved across all kingdoms, named for their soluble cytoplasmic ATPase subunits, also known as ATP-binding proteins or Traffic ATPases. Inner membrane translocation is facilitated by associated permease subunits or domains. Periplasmic binding proteins facilitate ABC uptake systems.
Details:
ABC transporters import and export a variety of substrates in E. coli and humans, and include multidrug exporters and the diseased proteins of cystic firbrosis in humans. Import ABC transporters can include permease and periplasmic binding protein subunits; export ABC transporters can include permease proteins or domains that work with Outer membrane factor (OMF) proteins such as TolC and specific membrane-fusion proteins. Most ABC family ATP-binding proteins have been shown to be ATPases supplying energy to the ABC permeases of multicomponent ABC transporters, while some ABC family ATPases provide energy for non-transport processes.
There are two permease proteins, AfuB' and PhnE', that appear to be mutated and are classifeid as pseudogenes.
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