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TopicPage for thiB 5' UTR of Escherichia coli K-12

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thiBPQ operon expression is controlled by a thiamine pyrophosphate (TPP) responsive riboswitch in the 128 nt 5' UTR. This THI element has been reported in intergenic sRNA searches as sroA/tpe79. The thiB riboswitch is the target for the antibiotic pyrithiamine.


The attenuation of transcription at the TPP-bound riboswitch produces the 93 nt sroA sRNA, ending at 75608.

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