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TopicPage for ribB 5' UTR of Escherichia coli K-12

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Riboswitches         

Description:

ribB expression is apparently controlled by a flavin mononucleotide (FMN) responsive riboswitch in the 253 nt 5' UTR. This RFN element 5' UTR has been reported in intergenic sRNA searches as sroG Vogel (2003).

Details:

Attenuation of transcription at the FMN-bound riboswitch produces the 149 nt sroG sRNA, ending at 3182592. The experimentally determined RNA start for sroG is the start of the ribB mRNA. sroG is not annotated as a separate gene and the sroG transcript is part of the ribB mRNA.

Mutations in the ribB riboswitch resulting in excretion of riboflavin were isolated as genetic suppressors of a rutE mutation allowing growth on pyrimidines at 37C (Kim, 2010).


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