Welcome to !

EcogeneTopic Page

TopicPage for LysR Transcriptional Regulator Family of Escherichia coli K-12

View Genes On Map

Transcription Factors Transcriptional Regulator Families         

Description:

The LysR-Type Transcriptional Regulators (LTTRs) are a group of related transcription factors that can activate or repress transcription by affecting the efficiency of transcription initiation (Henikoff, 1988; Maddocks, 2008). The LysR family is within the Helix-Turn-Helix (HTH) superfamily of DNA binding proteins.

Details:

48 E. coli paralogs belong to the LysR Family of transcriptional regulators as identified by matches to COG0583, including LysR itself. Three of the LTTRs are pseudogenes: YagP', YfaH' and YqfE'. YagP' is a deletion pseudogene comprised of the C-terminal 112/249 amino acids of intact YfaP present in E. coli O157:H7 Sakai (ECs0305). YfaH' is a deletion pseudogene comprised of the C-terminal 80/292 amino acids of intact YfaH present in E. coli O157:H7 (Z3495). YqfE' is a deletion pseudogene comprised of the C-terminal 106/298 amino acids of intact YqfE present in E. coli B354 (ECEG_02279). YagP' is not expected to be active but it may be expressed as part of a fusion with the adjacent N-terminal fragment-encoding pseudogene ykgT'. YfaH' and YqfE' are not expected to be expressed or to be active if artificially expressed.


Bibliography (7 total) : Review Only   Up