GenePage for the alaS gene of Escherichia coli K-12

Primary Gene Name: alaS
EcoGene Accession Number: EG10034
K-12 Gene Accession Number: ECK2692
MG1655 Gene Identifier: b2697
Gene Name Mnemonic: Alanine
Alternate Gene Symbols: act; ala-act; lovB
Description: Alanine--tRNA ligase, autorepressor
  # bp Upstream # bp Downstream
Verified Start MW: 96032.40 ---------876 aa Pre-Run BlastP UniProt
Pre-Run BlastP NR+Env
Left End: 2819381
Left Intergenic Region

Name: csrA_alaS

Length: 234 bp gap

Orientation: Codirectional-

Left_end: 2819147

Right_end: 2819380

Centisome: 60.74

Genomic Address
Counterclockwise
Minute or Centisome (%) = 60.74
Right End: 2822011
Right Intergenic Region

Name: alaS_recX

Length: 127 bp gap

Orientation: Codirectional-

Left_end: 2822012

Right_end: 2822138

Centisome: 60.80

alaS is an essential gene (Jasin, 1984). The alaS mutants in the Keio collection have been shown to harbor an intact copy of alaS in addition to the deletion allele (Yamamoto, 2009). AlaS binds to the alaS promoter region and autoregulates its own gene expression in response to the intracellular alanine concentration (Putney, 1981a).

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BamHI EcoRI HindIII