GenePage for the bioB gene of Escherichia coli K-12

Primary Gene Name: bioB
EcoGene Accession Number: EG10118
K-12 Gene Accession Number: ECK0764
MG1655 Gene Identifier: b0775
Gene Name Mnemonic: Biotin
Alternate Gene Symbols: None
Description: Biotin synthase; dethiobiotin to biotin pathway; iron-sulfur enzyme
  # bp Upstream # bp Downstream
Verified Start MW: 38648.09 ---------346 aa Pre-Run BlastP UniProt
Pre-Run BlastP NR+Env
Left End: 809344
Left Intergenic Region

Name: bioA_bioB

Length: 86 bp gap

Orientation: Divergent

Left_end: 809258

Right_end: 809343

Centisome: 17.43

Genomic Address
Clockwise
Minute or Centisome (%) = 17.44
Right End: 810384
Right Intergenic Region

Name: bioB_bioF

Length: 4 bp overlap

Orientation: Codirectional+

Left_end: 810381

Right_end: 810384

Centisome: 17.46

Radical SAM superfamily. BioB contains two distinct Fe-S cluster binding sites, one site accommodates a [2Fe-2S](2+) cluster with partial noncysteinyl ligation, the other site accommodates a [4Fe-4S](2+,+) cluster that binds S-adenosylmethionine (SAM) at a unique Fe site of the [4Fe-4S](2+) cluster and undergoes O(2)-induced degradation via a distinct type of [2Fe-2S](2+) cluster intermediate.

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BamHI EcoRI HindIII