GenePage for the cirA gene of Escherichia coli K-12

Primary Gene Name: cirA
EcoGene Accession Number: EG10155
K-12 Gene Accession Number: ECK2148
MG1655 Gene Identifier: b2155
Gene Name Mnemonic: Colicin I resistance/receptor
Alternate Gene Symbols: cir; feuA
Description: Colicin IA outer membrane receptor and translocator; ferric iron-catecholate transporter
  # bp Upstream # bp Downstream
Verified Start MW: 73895.73 ---------663 aa Pre-Run BlastP UniProt
Pre-Run BlastP NR+Env
Left End: 2244778
Left Intergenic Region

Name: yeiG_cirA

Length: 31 bp gap

Orientation: Convergent

Left_end: 2244747

Right_end: 2244777

Centisome: 48.36

Genomic Address
Counterclockwise
Minute or Centisome (%) = 48.36
Right End: 2246769
Right Intergenic Region

Name: cirA_lysP

Length: 293 bp gap

Orientation: Codirectional-

Left_end: 2246770

Right_end: 2247062

Centisome: 48.40

CirA transports ferric iron-catecholates into cells and the primary function of CirA may be to recapture the hydrolytic products of enterobactin, such as 2,3-dihydroxybenzoic acid and 2,3-dihydroxybenzoylserine (Nikaido, 1990). CirA mediates TonB-dependent translocation of Colicin IA into cells (Jakes, 2010). CirA is a member of the Outer Membrane Receptor (OMR) family of ligand-gated protein channels that utilizes the proton motive force (PMF) and the TonB-ExbB-ExbD complex for iron-siderophore, colicin and microcin uptake. The OMR family belongs to the Porin superfamily and deletions in OMR family proteins can restore a passive diffusion channel function typical of normal OM porins.

Go to GenePageGo to GenePageGo to GenePageGo to GenePageGo to GenePageGo to GenePageGo to GenePageGo to GenePageGo to GenePageGo to GenePageGo to GenePageGo to GenePageGo to GenePageGo to GenePageGo to GenePageGo to GenePageGo to GenePageGo to GenePageGo to GenePageGo to GenePageGo to GenePageGo to GenePageGo to GenePageGo to GenePageGo to GenePageGo to GenePageGo to GenePage

BamHI EcoRI HindIII