GenePage for the fecA gene of Escherichia coli K-12

Primary Gene Name: fecA
EcoGene Accession Number: EG10286
K-12 Gene Accession Number: ECK4281
MG1655 Gene Identifier: b4291
Gene Name Mnemonic: Ferric citrate
Alternate Gene Symbols: None
Description: TonB-dependent outer membrane ferric citrate transporter; signal transducer: ferric citrate extracelluar receptor and transmembrane signaling transmittor to the periplasmic sigma-19 activating protein FecR; ferric citrate uptake and iron utilization
  # bp Upstream # bp Downstream
Verified Start MW: 85321.61 ---------774 aa Pre-Run BlastP UniProt
Pre-Run BlastP NR+Env
Left End: 4514353
Left Intergenic Region

Name: fecB_fecA

Length: 44 bp gap

Orientation: Codirectional-

Left_end: 4514309

Right_end: 4514352

Centisome: 97.26

Genomic Address
Counterclockwise
Minute or Centisome (%) = 97.26
Right End: 4516677
Right Intergenic Region

Name: fecA_fecR

Length: 86 bp gap

Orientation: Codirectional-

Left_end: 4516678

Right_end: 4516763

Centisome: 97.31

The cytoplasmic C-terminal domain of FecR is an anti-sigma-19 factor, but sigma-19 (FecI) also requires FecR to function; in the absence of ferric citrate FecI is bound to the membrane by the cytoplasmic domain of the FecR transmembrane signal transducer, which both sequesters FecI and activates or protects FecI; exogenous ferric citrate induces outer membrane transmembrane transducer FecA to signal inner membrane transmembrane transducer FecR to release membrane-bound FecI to bind cytoplasmic core RNA polymerase and activate Fur-dependent fec operon transcription to allow ferric citrate import and relief of iron starvation (Braun, 2006; TreviƱo-Quintanilla, 2013). The Fec iron uptake and transmembrane signaling diferric dicitrate substrate [Fe(3+) citrate]2, is more simply referred to as ferric citrate (Braun, 2005).

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BamHI EcoRI HindIII