GenePage for the fic gene of Escherichia coli K-12

Primary Gene Name: fic
EcoGene Accession Number: EG10307
K-12 Gene Accession Number: ECK3349
MG1655 Gene Identifier: b3361
Gene Name Mnemonic: Filamentation-cAMP
Alternate Gene Symbols: vhpT(B.s.)
Description: Stationary phase-induced protein, putative toxin
  # bp Upstream # bp Downstream
MW: 22960.03 ---------200 aa Pre-Run BlastP UniProt
Pre-Run BlastP NR+Env
Left End: 3490861
Left Intergenic Region

Name: pabA_fic

Length: 31 bp gap

Orientation: Codirectional-

Left_end: 3490830

Right_end: 3490860

Centisome: 75.21

Genomic Address
Counterclockwise
Minute or Centisome (%) = 75.21
Right End: 3491463
Right Intergenic Region

Name: fic_yhfG

Length: 11 bp overlap

Orientation: Codirectional-

Left_end: 3491453

Right_end: 3491463

Centisome: 75.22

A G55R Fic mutant forms cAMP-induced filaments at elevated temperatures (Utsumi, 1982). The B. schoenbuchensis YhfG homolog antitoxin VhpA binds to and inhibits the adenylyltransferase toxin VhpT that is homologous to Fic (Engel, 2012). Fic/YhfG may constitute a toxin/antitoxin pair (Yamaguchi, 2011). Fic is related to the phage P1 protein kinase toxin Doc (Pfam PF02661) and contains a variant Fido domain (HxFx[D/E]GSGLxxR) that could have either protein kinase or adenosine monophosphate-protein transferase activity (Kinch, 2009; Engel, 2012; Castro-Roa, 2013). fic is RpoS-regulated during stationary phase (Tanaka, 1993; Utsumi, 1993; Tanaka, 1995; Utsumi, 1995; Miksch, 1995). Although Fic was reported to be similar to FtsA, this similarity is not obvious and is not statistically significant (Kawamukai, 1989). OtherPDB (B. schoenbuchensis): 3SHG. OtherPDB (H. somnus): 3N3V. otherPDB (V. parahaemolyticus): 3LET.

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BamHI EcoRI HindIII