GenePage for the fimD gene of Escherichia coli K-12

Primary Gene Name: fimD
EcoGene Accession Number: EG10311
K-12 Gene Accession Number: ECK4308
MG1655 Gene Identifier: b4317
Gene Name Mnemonic: Fimbriae
Alternate Gene Symbols: None
Description: Fimbrial usher outer membrane porin protein; export, assembly and anchoring of type 1 fimbriae (pili); FimCD chaperone-usher
  # bp Upstream # bp Downstream
Verified Start MW: 96482.39 ---------878 aa Pre-Run BlastP UniProt
Pre-Run BlastP NR+Env
Left End: 4545096
Left Intergenic Region

Name: fimC_fimD

Length: 66 bp gap

Orientation: Codirectional+

Left_end: 4545030

Right_end: 4545095

Centisome: 97.92

Genomic Address
Clockwise
Minute or Centisome (%) = 97.92
Right End: 4547732
Right Intergenic Region

Name: fimD_fimF

Length: 9 bp gap

Orientation: Codirectional+

Left_end: 4547733

Right_end: 4547741

Centisome: 97.98

The multi-domain dimeric FimD usher protein has an N-terminal periplasmic chaperone-pilin (fimbrial subunit) complex-binding domain and a porin-like beta barrel outer membrane transport and anchoring domain that forms twin pores in the outer membrane which can be blocked by a periplasmic middle-pore plug domain; a C-terminal periplasmic domain facilitates fimbria (pilus) assembly (Klemm, 1900; Saulino, 1998; Saulino, 2002; Thanassi, 2002; Barnhart, 2003; Nishiyama, 2003; Sauer, 2004; Li, 2004; Capitani, 2006; So, 2006; Remaut, 2008). The crystal structure of the pilus elongation complex in which the tip complex assembly composed of FimC, FimF, FimG and FimH passes through the usher porin FimD has been determined (Geibel, 2013). The first 45 aa of FimD constitute a cleavable type I signal peptide. Some of the detailed features of FimD structure and function are extrapolated from experiments with the homologous PapC usher protein of uropathogenic E. coli.

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BamHI EcoRI HindIII